1. don't move your samples; LoopAZoid can't know about this and won't find them when your songs are re-loaded.
2. you won't be able to use your song files (*.all for Cubase, *.lso for Logic) on a different computer, even if the samples are in the same place!
3. when you re-install your OS, all your sample references will be lost!!!
To avoid these situations, always export your samples as patches, too!
LoopAZoid has it's patch import / export functionality exactly for these reasons. It's good practice to eventually make a patch for every LoopAZoid instance in every song! You can backup these patches, exchange them with others, transfer them to another computer, and they'll survive an OS re-install.
The easy handling makes the above drawbacks necessary - but it's a fair deal, if you take into account, that most of the time you don't need to bother at all about where your samples are! Instead you can just load them, with the machine finding them automatically afterwards - and everything will be just fine if you follow this guideline.
NOTE: if you have many different songs and you don't want to export patches for all of them, here is a tutorial how you can back up and restore your sample list.
